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(PDF) Worlds top 2% Scientist 2022 - ResearchGate. The US-based Stanford University has released year 2022 list that represents the top 2% of the most-cited scientists in various disciplines. The exhaustive list has 200409 persons across the globe .. Top 2% Scientists Worldwide 2022 by Stanford …. 20 Oct 2022
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. 1 / 1. Twenty-one PolyU Science members are ranked as the World’s Top 2% most-cited scientists by Stanford University
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. Targeting DNA topoisomerase II in cancer chemotherapy …yan jami"a
. Nature Reviews Cancer - The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer …. Nucleolar translocation of human DNA topoisomerase II …. DNA topoisomerase II (TOP2) is a nuclear protein that resolves DNA topological problems and plays critical roles in multiple nuclear processes. Human cells … top2. Human topoisomerases and their roles in genome stability and. Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA …. Inhibition of topoisomerase IIA (Top2α) induces telomeric …. Kankanala, J top2. et al. Novel deazaflavin analogues potently inhibited tyrosyl DNA phosphodiesterase 2 (TDP2) and strongly sensitized cancer cells toward treatment …. Structural basis for allosteric regulation of Human . - Nature top2. Nature Reviews Molecular Cell Biology (2022) The human type IIA topoisomerases (Top2) are essential enzymes that regulate DNA topology and …. ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA. Resolving a DNA-protein cross-link. Topoisomerase 2 (TOP2) creates DNA double-strand breaks to regulate DNA topology and is critical for processes such as …. Recurrent mutations in topoisomerase IIα cause a previously top2. Here, we have identified a somatic alteration in hTOP2α (p.K743N) in human tumors that causes a remarkably specific pattern of indel mutagenesis that we name ID_TOP2αbodega jean bousquet
. We …. Topoisomerase IIα represses transcription by enforcing promoter .. To study a possible function of TOP2 and DNA supercoiling in regulating transcription, changes in gene expression profiles were analyzed in human-telomerase …
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. TOP2 is subsequently sumoylated by ZNF451, enabling the recruitment of tyrosyl-DNA phosphodiesterase 2 (TDP2), which contains a split SUMO interaction motif required for its recruitment. top2. Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes. DNA topoisomerases regulate the topological state of DNA, relaxing DNA supercoils and resolving catenanes and knots that result from biologic processes, such as transcription and replication. DNA topoisomerase II (TOP2) enzymes achieve this by binding DNA and introducing an enzyme-bridged DNA double-strand break (DSB) where each …. Topoisomerase II-Induced Chromosome Breakage and Translocation …. Cohesin-mediated loop extrusion and associated TOP2 activity occur largely independently of transcription (Canela et al., 2017, Vian et al., 2018).Given that elevated TOP2-induced translocations in TDP2-defective cells are transcription dependent (Gómez-Herreros et al., 2017), we wished to explore further the relationship between TOP2 … top2
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. SUMOylation may also act to recruit other repair factors or act as a scaffold, regulating protein interactions, which may ultimately dictate the cellular decision to choose one pathway of repair verses another. It is posited that .. Etoposide, an anticancer drug involved in therapy-related …. TOP2 (alpha and beta isoforms) are ubiquitous enzymes that plays a vital role in many basic DNA processes and regulates the under- and over-winding of DNA during DNA replication. TOP2 inhibitors play an integral role in cancer treatment due to the collapse/collision of the resultant bifurcation and unsolved DSB, leading to cancer cell …. Etoposide, an anticancer drug involved in therapy-related secondary .. TOP2 (alpha and beta isoforms) are ubiquitous enzymes that plays a vital role in many basic DNA processes and regulates the under- and over-winding of DNA during DNA replication. TOP2 inhibitors play an integral role in cancer treatment due to the collapse/collision of the resultant bifurcation and unsolved DSB, leading to cancer cell … top2. TOP2 synergizes with BAF chromatin remodeling for bothγιατι κλαιει το μωρο το βραδυ
. TOP2 collaborates with the BAF complex genome-wide to form and resolve facultative heterochromatin at transcriptional regulatory elements recognized by pluripotency factors. The resolution and .. Structural insights into the gating of DNA passage by the top2. - Nature top2. Top2 cleavage complex structure reveals opening of DNA-gate. Crystallization has been recognized as an effective approach for sampling energetically accessible conformational states of proteins .. THEBEN TR TOP2 TIMER MANUAL | ManualsLib. Theben TR 652 S, TR 651 S, TR 653 - Digital Timer Quick Start Guide. (article) Timer Theben TR 644 S Operating Instructions Manual top2power of love πως ψηφιζω
. Time switch programming with software obelisk (30 pages) Timer Theben SELEKTA top2 Series Manual. Astronomical time switches with weekly program (118 pages) Timer Theben TC 649 C Manual. top2. Structural basis of DNA topoisomerase II-α (Top2-α) inhibition: a .. Molecular model of Top2-αgot asat magas
. Although the crystal structure of human Top2β-DNA in complex with Mitoxantrone and Amsacrine as anticancer drugs has been reported (Wu et al., 2013), there is no information available on the interaction of Top2-α with these inhibitors.In the present study, several docking analysis was performed to understand the …
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